Activity of OPT-80, a novel macrocycle, compared with those of eight other agents against selected anaerobic species.
نویسندگان
چکیده
Agar dilution MIC was used to compare activities of OPT-80, linezolid, vancomycin, teicoplanin, quinupristin/dalfopristin, amoxicillin/clavulanate, imipenem, clindamycin, and metronidazole against 350 gram-positive and -negative anaerobes. OPT-80 was active against gram-positive strains only, especially Clostridium spp. (85 strains tested, including 21 strains of C. difficile), with MICs ranging between </=0.016 and 0.25 microg/ml.
منابع مشابه
In vitro activity of OPT-80 against Clostridium difficile.
Clostridium difficile remains the major cause of nosocomial diarrhea. Reports on impaired susceptibility of C. difficile to metronidazole and vancomycin and frequent relapses of patients after therapy necessitate the search for new substances. With this study, the activity of OPT-80, a new macrocycle, against 207 C. difficile strains and against other obligately anaerobic bacteria was tested. O...
متن کاملIn vitro activities of OPT-80 and comparator drugs against intestinal bacteria.
The activities of OPT-80 against 453 intestinal bacteria were compared with those of seven other drugs. OPT-80 showed good activity against most clostridia, staphylococci, and enterococci, but streptococci, aerobic and facultative gram-negative rods, anaerobic gram-negative rods, and Clostridium ramosum were resistant. Poor activity against anaerobic gram-negative rods may maintain colonization...
متن کاملAntagonistic Activity of Bacteriocin- Producing Lactobacillus local isolates against some pathogenic bacterial species
Background and Objective: Lactobacilli are known for their probiotic activities and potential to combat pathogens. This study aimed to investigate the antimicrobial activity of Lactobacillus strains isolated from various sources against pathogenic bacteria, with the objective of identifying potential bacteriocin producers. Methods: A total of 140 samples were collected from different sources. ...
متن کاملIn vitro activity of cefotetan compared with that of other antimicrobial agents against anaerobic bacteria.
The activity of cefotetan against 430 strains of anaerobic bacteria was compared with that of cefoxitin, ceftizoxime, clindamycin, metronidazole, and chloramphenicol. Percent susceptible values for the Bacteroides fragilis group were 60, 80, 29, 86, 100, and 100%, respectively. Percent susceptible values for the B. fragilis species were 91, 92, 46, 98, 100, and 100%, respectively. Non-B. fragil...
متن کاملIsoflavonoids isolated from Smirnowia iranica as new antiprotozoal agents
The Leguminosae (Fabaceae) is the second-largest family of flowering plants and contains 657 genera and about 16400 species. It includes more important drugs than any other family. Apart from a report on description of the species in Iran, the literature lists only reports of photosynthesis and carbon dioxide exchange in the plant, and also three reports on isolation of alkaloids named smirnovi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 48 11 شماره
صفحات -
تاریخ انتشار 2004